18F-FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease.

Yeona KangClaire HenchcliffeAjay VermaShankar VallabhajosulaBin HeParesh J KothariKane O PryorP David Mozley

Published in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2018)

mGluR5 seems upregulated in strategic dopaminergic brain regions adversely affected by PD. The findings seem to confirm that DaT tracers are better discriminatory biomarkers for diagnosing PD; however, mGluR5 tracers might deserve further exploration as potential biomarkers of response in clinical trials.

Keyphrases

pet ct
clinical trial
positron emission tomography
poor prognosis
white matter
cell proliferation
signaling pathway
multiple sclerosis
long non coding rna
phase iii
double blind