Metabolic impairments associated with type 2 diabetes mellitus and the potential effects of exercise therapy: An exploratory randomized trial based on untargeted metabolomics.
Furong ZhangXixi ChenMingxiao YangXiaoyu ShenYiliang WangDongling ZhongFang ZengRongjiang JinPublished in: PloS one (2024)
T2DM patients displayed impaired carbohydrate, lipid, and amino acid metabolism, and exercise therapy improved their metabolic health. Different modalities may act through different pathways. Tai Chi may improve disrupted BCAAs metabolism, whereas brisk walking mainly regulates steroid hormone biosynthesis and arachidonic acid metabolism.
Keyphrases
- end stage renal disease
- mass spectrometry
- amino acid
- ejection fraction
- physical activity
- newly diagnosed
- healthcare
- mental health
- type diabetes
- patient reported outcomes
- human health
- fatty acid
- skeletal muscle
- cardiovascular disease
- weight loss
- bone marrow
- resting state
- cell therapy
- functional connectivity
- body composition
- climate change
- simultaneous determination