Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group.
D E W van der KruijssenS G EliasP M van de VenK L van RooijenJ 't Lam-BoerL MolC J A PuntD W SommeijerP J TanisJ D NielsenM K YilmazJ M G H van RielD K Wasowiz-KempsO J L LoosveldG P van der SchellingJ W B de GrootH L van WestreenenH L JakobsenA L FrommP HambergM VerseveldC JaenschG I LipositsP van DuijvendijkJ Oulad HadjJ A B van der HoevenM TrajkovicJ H W de WiltM Koopmannull nullPublished in: Annals of oncology : official journal of the European Society for Medical Oncology (2024)
Addition of upfront PTR to palliative systemic therapy in patients with synchronous mCRC without severe symptoms of the primary tumor does not result in a survival benefit. This practice should no longer be considered standard of care.