Quantification of six potential unspecific human biomarkers of 1-vinyl-2-pyrrolidone exposure in Sprague-Dawley rat urine using gas chromatography coupled with triple mass spectrometry.
Jens BertramT SchettgenT KrausPublished in: Rapid communications in mass spectrometry : RCM (2018)
A quick and easy to use method has been established for six target molecules investigated for a better understanding of the metabolism of VP. Two of three substances identified as metabolites of VP could serve as a nonspecific human biomarker for VP exposure as shown with an excerpt of an exposure study performed in SD rats.
Keyphrases
- mass spectrometry
- gas chromatography
- endothelial cells
- tandem mass spectrometry
- induced pluripotent stem cells
- liquid chromatography
- pluripotent stem cells
- disease virus
- high resolution mass spectrometry
- ms ms
- high resolution
- oxidative stress
- drinking water
- gas chromatography mass spectrometry
- atomic force microscopy
- single molecule
- high speed