CD4+T cells in ageing-associated interstitial lung abnormalities show evidence of pro-inflammatory phenotypic and functional profile.

Carlos Machahua Ivette Buendia-Roldan Ranferi Ocaña-GuzmanMaría Molina-MolinaAnnie Pardo Leslie Chavez Galan Moisés Selman

Published in: Thorax (2020)

CD4+T cells from ILA subjects are highly proliferative and show an excessive functional activity, likely related to the loss of KLRG1 expression, which may contribute to an inflammatory state and the development of ILA.

Keyphrases

poor prognosis
oxidative stress
weight gain
binding protein
body mass index
physical activity