Xanthine oxidase inhibitory peptides derived from tuna protein: virtual screening, inhibitory activity, and molecular mechanisms.

Zhipeng YuRuotong KanSijia WuHui GuoWenzhu ZhaoLong DingFuping ZhengJingbo Liu

Published in: Journal of the science of food and agriculture (2020)

This study suggested that conventional hydrogen bond interactions and electrostatic interactions play an important role in XO inhibition. The novel XO inhibitory peptide EEAK from tuna protein could be used as potential candidate for controlling gout and hyperuricemia. © 2020 Society of Chemical Industry.

Keyphrases

uric acid
amino acid
protein protein
binding protein
metabolic syndrome
risk assessment
small molecule
human health