Proton pump inhibitor in upper gastrointestinal fecal microbiota transplant: A systematic review and analysis.
Annie S HongWen Yuan YuJenny M HongChad L CrossMohamed AzabGordon OhningMahendran JayarajPublished in: Journal of gastroenterology and hepatology (2020)
We did not find evidence supporting a clinically significant benefit from routine use of PPIs in FMT protocol. It is possible that the theoretical benefit from improved survival of transplanted microbiota is offset by negative effects on the microbiome. We suggest that routine use of PPIs in upper GI FMT be reconsidered. Further investigation is needed to optimize protocols for safety and efficacy.