The HIF-1α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma.

Yuan WangHongguang LianJiajun LiMan ZhaoZengfang HaoXue ZhengLinyuan ZhaoJinfeng Cui

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2024)

Different expression and clinical features of HIF-1α/PKM2 feedback loop was existed between LUAD and normal lung tissues, especially in EGFR mutational tumors, supporting the relationship between EGFR mutation and the key related proteins of aerobic glycolysis (HIF-1α and PKM2) in lung adenocarcinomas.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
endothelial cells
poor prognosis
transcription factor
gene expression
high intensity
binding protein
drug induced