Evaluation of a respiratory care protocol including less invasive surfactant administration in preterm infants.
Christina S ChanMelody ChiuSwathi AriyapadiL Steven BrownPatti BurchfieldValerie SimcikKristi GarciaKathryn MazionieneMambarambath A JaleelMyra H WyckoffVishal S KapadiaVenkatakrishna KakkilayaPublished in: Pediatric research (2023)
Less invasive surfactant administration (LISA) decreases the need for mechanical ventilation (MV) and improves outcomes. However, some infants require MV within 72 h of life (HOL) despite LISA (LISA failure). Over 80% of ≤29 weeks' gestational age (GA) infants can be successfully managed on CPAP with or without surfactant in the first 72 HOL. A combination of factors including ≤25 weeks' GA and fraction of inspired oxygen ≥0.3 an hour after LISA predict LISA failure. Evaluation of a noninvasive respiratory support strategy including LISA provides targets for intervention to decrease need for MV in preterm infants.
Keyphrases
- preterm infants
- gestational age
- mechanical ventilation
- low birth weight
- pet ct
- birth weight
- preterm birth
- randomized controlled trial
- healthcare
- obstructive sleep apnea
- palliative care
- type diabetes
- quality improvement
- physical activity
- skeletal muscle
- sleep apnea
- chronic pain
- pain management
- weight gain
- extracorporeal membrane oxygenation