Enhanced tuberculosis diagnosis with computer-aided chest X-ray and urine LAM in adults with HIV admitted to hospital (CASTLE study): A cluster randomised trial.
Rachael M BurkeSaulos K NyirendaTimeo MtengaHussein H TwabiElizabeth JoekesNaomi F WalkerRose NyirendaAnkur Gupta-WrightMarriott NliwasaKatherine FieldingPeter MacPhersonElizabeth L CorbettPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Urine SILVAMP-LAM/Determine-LAM plus dCXR-CAD diagnostics identified more hospitalised PHIV with TB than usual care. The increase in TB treatment appeared mainly due to greater use of Determine-LAM, rather than SILVAMP-LAM or dCXR-CAD. Poor concordance between Determine-LAM and SILVAMP-LAM urine tests requires further investigation. Inpatient mortality for adults with HIV remains unacceptability high.
Keyphrases
- mycobacterium tuberculosis
- antiretroviral therapy
- hiv infected
- hiv aids
- hiv positive
- healthcare
- human immunodeficiency virus
- coronary artery disease
- hepatitis c virus
- hiv testing
- palliative care
- high resolution
- clinical trial
- emergency department
- mental health
- randomized controlled trial
- men who have sex with men
- magnetic resonance imaging
- cardiovascular disease
- cardiovascular events
- magnetic resonance
- acute care
- study protocol
- pain management
- chronic pain