Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice.

Tamiris Lima RachidFlavia Maria Silva-VeigaFrancielle Graus-NunesIsabele BringhentiCarlos Alberto Mandarim-de-LacerdaVanessa Souza-Mello

Published in: PloS one (2018)

This work provides evidence that the PPAR-β/δ agonist ameliorated metabolic disorders through enhanced beta-oxidation and better tolerance to glucose, whereas the PPAR-α agonism was confirmed as a promising therapeutic target for treating metabolic diseases via beige cell induction and enhanced thermogenesis.

Keyphrases

adipose tissue
insulin resistance
high fat diet
fatty acid
metabolic syndrome
type diabetes
skeletal muscle
weight loss
blood pressure
cell therapy