Identification of Poliovirus Receptor-like 3 Protein as a Prognostic Factor in Triple-Negative Breast Cancer.
Gian Marco LeoneKatia ManganoSalvatore CaponnettoPaolo FagoneFerdinando NicolettiPublished in: Cells (2024)
Triple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer, with a bad prognosis and lack of targeted therapeutic options. Characterized by the absence of estrogen receptors, progesterone receptors, and HER2 expression, TNBC is often associated with a significantly lower survival rate compared to other breast cancer subtypes. Our study aimed to explore the prognostic significance of 83 immune-related genes, by using transcriptomic data from the TCGA database. Our analysis identified the Poliovirus Receptor-Like 3 protein (PVRL3) as a critical negative prognostic marker in TNBC patients. Furthermore, we found that the Enhancer of Zeste Homolog 2 (EZH2), a well-known epigenetic regulator, plays a pivotal role in modulating PVRL3 levels in TNBC cancer cell lines expressing EZH2 along with high levels of PVRL3. The elucidation of the EZH2-PVRL3 regulatory axis provides valuable insights into the molecular mechanisms underlying TNBC aggressiveness and opens up potential pathways for personalized therapeutic intervention.
Keyphrases
- prognostic factors
- transcription factor
- binding protein
- long non coding rna
- long noncoding rna
- end stage renal disease
- ejection fraction
- poor prognosis
- newly diagnosed
- estrogen receptor
- papillary thyroid
- dna methylation
- single cell
- squamous cell carcinoma
- patient reported outcomes
- risk assessment
- climate change
- machine learning
- adverse drug
- rna seq
- human health
- data analysis
- lymph node metastasis