Evaluation of DNA methylation of inflammatory genes following treatment of chronic periodontitis: A pilot case-control study.
Farah Asa'adValentina BollatiGiorgio PagniRogerio M CastilhoEleonora RossiFrancesca PomingiLetizia TarantiniDario ConsonniWilliam V GiannobileGiulio RasperiniPublished in: Journal of clinical periodontology (2017)
Periodontal therapy resets the DNA methylation status of inflammatory gene for COX-2 in patients with periodontal disease. DNA methylation levels of TNF-α, IFN-γ and LINE-1 were sustained in periodontitis sites despite therapy. Future studies should consider an expanded panel of inflammatory genes over time. (ClinicalTrials.gov NCT02835898).