Dupilumab-associated ocular surface disease is characterized by a shift from Th2/Th17 toward Th1/Th17 inflammation.

Kathrin ThormannAnne-Sophie LüthiFelix DeniauAnja HeiderSimone Cazzaniga Susanne Radonjic-HoesliMathias LehmannChristoph SchlapbachElio L HerzogMarco KreuzerMartin Sebastian Zinkernagel Mübeccel Akdis Denise C Zysset-Burri Hans-Uwe Simon Dagmar Simon

Published in: Allergy (2024)

DAOSD is characterized by a Th1/Th17 cytokine profile and an upregulation of markers known to promote remodeling and fibrosis. The expression pattern of inflammatory markers in tear fluids at baseline might serve as a prognostic factor for DAOSD.

Keyphrases

prognostic factors
poor prognosis
atopic dermatitis
oxidative stress
long non coding rna
cell proliferation
signaling pathway
binding protein
liver fibrosis