Effects of Electroacupuncture on Ovarian Expression of the Androgen Receptor and Connexin 43 in Rats with Letrozole-Induced Polycystic Ovaries.

Ge Xu An-Dong Zhang Jiandang LiuXi WangJiwei FengYue-Lai Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

In conclusion, our results showed that EA can ease hyperandrogenism and polycystic ovary morphology in PCOS rats. Furthermore, EA counteracted the letrozole-induced upregulation of AR and Cx43. These results suggested that acupuncture can break the vicious cycle initiated by excessive androgen secretion and may be an effective treatment method for improving the reproductive and endocrine dysfunction caused by PCOS.

Keyphrases

polycystic ovary syndrome
high glucose
poor prognosis
diabetic rats
insulin resistance
oxidative stress
drug induced
type diabetes
cell proliferation
signaling pathway
neuropathic pain
endothelial cells
adipose tissue
weight gain
physical activity
early breast cancer
weight loss
subarachnoid hemorrhage