Metformin as targeted treatment in fragile X syndrome.

A B C DyF TassoneM EldeebMaria Jimena Salcedo-ArellanoN TartagliaR Hagerman

Published in: Clinical genetics (2017)

We recommend a controlled trial of metformin in those with FXS. Metformin appears to be an effective treatment of obesity including those with the PWP in FXS. Our study suggests that metformin may also be a targeted treatment for improving behavior and language in children and adults with FXS.

Keyphrases

metabolic syndrome
type diabetes
randomized controlled trial
weight loss
body mass index
combination therapy
skeletal muscle
autism spectrum disorder
replacement therapy
smoking cessation