lnc-RHL, a novel long non-coding RNA required for the differentiation of hepatocytes from human bipotent progenitor cells.

Bindu PrabhakarSoowan LeeAdara BochanisWu HeJosé E ManautouTheodore P Rasmussen

Published in: Cell proliferation (2021)

Deficiency for lnc-RHL in HepaRG cells converts them from bipotent progenitor cells to unipotent progenitor cells with impaired ability to yield hepatocytes. We conclude that lnc-RHL is a key regulator of bipotency in HepaRG cells.

Keyphrases

long non coding rna
induced apoptosis
cell cycle arrest
poor prognosis
endothelial cells
endoplasmic reticulum stress
liver injury
cell proliferation
smoking cessation