SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.

Takuro MatsumotoHirokazu OkayamaShotaro NakajimaKatsuharu SaitoMisato ItoAkinao KanetaYasuyuki KankeHisashi OnozawaSuguru HayaseShotaro FujitaWataru SakamotoMotonobu SaitoZenichiro SezeTomoyuki MommaKousaku MimuraKoji Kono

Published in: British journal of cancer (2021)

Our findings suggest that downregulation of multiple genes on chromosome 8p, including SH2D4A, cooperatively contribute to tumorigenesis, resulting in the immune cold tumour microenvironment and poor prognosis.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
copy number
signaling pathway
stem cells
genome wide
gene expression
bioinformatics analysis
genome wide identification