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Imaging Sigma-1 Receptor (S1R) Expression Using Iodine-124-Labeled 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine ([124I]IPAG).

Kishore K GangangariAndrás VáradiSusruta MajumdarSteven M LarsonGavril W PasternakNaga Vara Kishore Pillarsetty
Published in: Molecular imaging and biology (2021)
[124I]IPAG was synthesized successfully in high yields, and in vitro and in vivo studies demonstrate specificity of [124I]IPAG. [124I]IPAG shows specific accumulation in tumors with increasing tumor to background ratio at later time points and therefore has high potential for imaging S1R-overexpressing cancers.
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