Ischemic Etiology and Prognosis in Men and Women with Acute Heart Failure.
Lourdes VicentJosé M GuerraRafael Vazquez-GarciaJosé R Gonzalez-JuanateyLuis Martínez DolzJavier SegoviaDomingo Pascual FigalRamón BoverFernando WornerJuan Francisco DelgadoFrancisco Fernández-AvilésManuel Martinez-SellésPublished in: Journal of clinical medicine (2021)
Coronary heart disease is common in heart failure (HF). Our aim was to determine the impact of ischemic etiology on prognosis among men and women with HF. This study is a prospective national multicenter registry. The primary endpoint was 12-month mortality. Patients with HF and ischemic heart disease were stratified according to sex. A total of 1830 patients were enrolled of which 756 (41.3%) were women. Ischemic etiology was more common in men (446 (41.6%)) than in women (167 (22.2%)). Among patients with ischemic HF, diabetes was more frequent in women than in men. Ischemic etiology was not associated with higher mortality risk, and this was true for women (Hazard Ratio [HR] 1.51, 95% Confidence Interval [CI] 0.98-2.32; p = 0.61) and men (HR 1.14, 95% CI 0.81-1.61; p = 0.46), p-value for interaction: 0.067. Mortality/readmission risk in ischemic HF increased in men with previous readmissions (HR 1.15, 95% CI 1.02-1.29; p = 0.022), chronic obstructive pulmonary disease (HR1.20, 95% CI 1.02-1.41; p = 0.026) and in women with diabetes (HR 2.23, 95% CI 1.05-4.47; p = 0.035). Ischemic etiology was not associated with mortality in HF patients. In ischemic HF, the variables associated with a poor prognosis were diabetes in women and previous readmissions and chronic obstructive pulmonary disease in men.
Keyphrases
- acute heart failure
- heart failure
- polycystic ovary syndrome
- chronic obstructive pulmonary disease
- poor prognosis
- ischemia reperfusion injury
- end stage renal disease
- cerebral ischemia
- type diabetes
- middle aged
- cardiovascular disease
- pregnancy outcomes
- ejection fraction
- chronic kidney disease
- newly diagnosed
- cardiovascular events
- prognostic factors
- peritoneal dialysis
- long non coding rna
- breast cancer risk
- pregnant women
- atrial fibrillation
- risk factors
- patient reported outcomes
- subarachnoid hemorrhage
- lung function
- oxidative stress
- cystic fibrosis
- air pollution
- weight loss
- adipose tissue
- quality improvement
- cardiac resynchronization therapy