Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.
Yusuke KawamuraHirofumi NakaokaAkiyoshi NakayamaYukinori OkadaKen YamamotoToshihide HigashinoMasayuki SakiyamaToru ShimizuHiroshi OoyamaKeiko OoyamaMitsuo NagaseYuji HidakaYuko ShirahamaKazuyoshi HosomichiYuichiro NishidaIppei ShimoshikiryoAsahi HishidaSakurako Katsuura-KamanoSeiko ShimizuMakoto KawaguchiHirokazu UemuraRie IbusukiMegumi HaraMariko NaitoMikiya TakaoMayuko NakajimaSatoko IwasawaHiroshi NakashimaKeizo OhnakaTakahiro NakamuraBlanka StiburkovaTony R MerrimanMasahiro NakatochiSahoko IchiharaMitsuhiro YokotaTappei TakadaTatsuya SaitohYoichiro KamataniAtsushi TakahashiKokichi ArisawaToshiro TakezakiKeitaro TanakaKenji WakaiMichiaki KuboTatsuo HosoyaKimiyoshi IchidaIturo InoueNariyoshi ShinomiyaHirotaka MatsuoPublished in: Annals of the rheumatic diseases (2019)
This meta-analysis is the first to reveal the loci associated with crystal-induced inflammation, the last step in gout development that aggravates AHUA into gout. Our findings should help to elucidate the molecular mechanisms of gout development and assist the prevention of gout attacks in high-risk AHUA individuals.