An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells.

Misa YoshidaChihiro OdaKeishiro MishimaItsuki TsujiSatoshi Obika Masahito Shimojo

Published in: Cancer cell international (2023)

Our data demonstrate that a gapmer ASO targeting SRRM4 (SRRM4 ASO) reduces cell viability through splicing changes of REST, followed by affecting REST-controlled genes in recalcitrant tumors SCLC and PCa cells.

Keyphrases

nucleic acid
small cell lung cancer
induced apoptosis
cancer therapy
cell cycle arrest
genome wide
big data
endoplasmic reticulum stress
cell death
dna methylation
data analysis
transcription factor
pi k akt