Satoshi Obika (Saoshi Obika)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 72

Top Topics

Mass Spectrometry

Small Cell Lung Cancer

Quality Control

Top Venues

The Journal of organic chemistry

Nucleic acids research

Molecules (Basel, Switzerland)

Bioconjugate chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Hiroto Kohashi, Ryu Nagata, Yusuke Tamenori, Tomorrow Amatani, Yoshifumi Ueda, Yasuo Mori, Yuuya Kasahara, Satoshi Obika, Masahito Shimojo
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic acids research 52 (9) (2024)
Qin Ren, Takashi Osawa, Michiaki Tatsuno, Satoshi Obika
THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides. RSC advances 14 (30) (2024)
Wenting Huo, Koji Miki, Huiying Mu, Takashi Osawa, Harumi Yamaguma, Yusuke Tamenori, Satoshi Obika, Yoshimasa Kawaguchi, Hisaaki Hirose, Shiroh Futaki, Yusuke Miyazaki, Wataru Shinoda, Shuji Akai, Kouichi Ohe
Light-controllable cell-membrane disturbance for intracellular delivery. Journal of materials chemistry. B (2024)
Hidekazu Hoshino, Yusuke Tamenori, Satoshi Obika
Polyamines promote xenobiotic nucleic acid synthesis by modified thermophilic polymerase mutants. RSC chemical biology 5 (5) (2024)
Hiroto Kohashi, Ryu Nagata, Yusuke Tamenori, Tomorrow Amatani, Yoshifumi Ueda, Yasuo Mori, Yuuya Kasahara, Satoshi Obika, Masahito Shimojo
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic acids research 52 (9) (2024)
Hidekazu Hoshino, Yusuke Tamenori, Satoshi Obika
Polyamines promote xenobiotic nucleic acid synthesis by modified thermophilic polymerase mutants. RSC chemical biology 5 (5) (2024)
Shogo Omuro, Takao Yamaguchi, Taiji Kawase, Kenji Hirose, Tokuyuki Yoshida, Takao Inoue, Satoshi Obika
Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry. Journal of the American Society for Mass Spectrometry (2024)
Hiroto Kohashi, Ryu Nagata, Yusuke Tamenori, Tomorrow Amatani, Yoshifumi Ueda, Yasuo Mori, Yuuya Kasahara, Satoshi Obika, Masahito Shimojo
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic acids research 52 (9) (2024)
Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, Satoshi Uchida, Satoshi Obika, Hyun Jin Kim, Kanjiro Miyata
Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry 35 (2) (2024)
Qin Ren, Takashi Osawa, Michiaki Tatsuno, Satoshi Obika
THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides. RSC advances 14 (30) (2024)
Hiroto Kohashi, Ryu Nagata, Yusuke Tamenori, Tomorrow Amatani, Yoshifumi Ueda, Yasuo Mori, Yuuya Kasahara, Satoshi Obika, Masahito Shimojo
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic acids research 52 (9) (2024)
Hiroto Kohashi, Ryu Nagata, Yusuke Tamenori, Tomorrow Amatani, Yoshifumi Ueda, Yasuo Mori, Yuuya Kasahara, Satoshi Obika, Masahito Shimojo
A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic acids research (2024)
Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, Satoshi Uchida, Satoshi Obika, Hyun Jin Kim, Kanjiro Miyata
Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry 35 (2) (2024)
Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, Satoshi Uchida, Satoshi Obika, Hyun Jin Kim, Kanjiro Miyata
Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry (2024)
Wenting Huo, Koji Miki, Huiying Mu, Takashi Osawa, Harumi Yamaguma, Yusuke Tamenori, Satoshi Obika, Yoshimasa Kawaguchi, Hisaaki Hirose, Shiroh Futaki, Yusuke Miyazaki, Wataru Shinoda, Shuji Akai, Kouichi Ohe
Light-controllable cell-membrane disturbance for intracellular delivery. Journal of materials chemistry. B 12 (17) (2024)
Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, Satoshi Uchida, Satoshi Obika, Hyun Jin Kim, Kanjiro Miyata
Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry 35 (2) (2024)
Misa Yoshida, Chihiro Oda, Keishiro Mishima, Itsuki Tsuji, Satoshi Obika, Masahito Shimojo
An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells. Cancer cell international 23 (1) (2023)
Takao Yamaguchi, Naohiro Horie, Hiroshi Aoyama, Shinji Kumagai, Satoshi Obika
Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N'-methylguanidine-bridged nucleic acids. Nucleic acids research (2023)
Misa Yoshida, Chihiro Oda, Keishiro Mishima, Itsuki Tsuji, Satoshi Obika, Masahito Shimojo
An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells. Cancer cell international 23 (1) (2023)
Takashi Osawa, Taiki Akino, Satoshi Obika
Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3',4'-Tetrahydropyran-Bridged Nucleic Acid. The Journal of organic chemistry (2023)
Hideo Takakusa, Norihiko Iwazaki, Makiya Nishikawa, Tokuyuki Yoshida, Satoshi Obika, Takao Inoue
Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs. Nucleic acid therapeutics (2023)
Sawa Miyagawa, Takahiro Horie, Tomohiro Nishino, Satoshi Koyama, Toshimitsu Watanabe, Osamu Baba, Tomohiro Yamasaki, Naoya Sowa, Chiharu Otani, Kazuki Matsushita, Hidenori Kojima, Masahiro Kimura, Yasuhiro Nakashima, Satoshi Obika, Yusuke Tamenori, Jun Kotera, Kozo Oka, Ryo Fujita, Takashi Sasaki, Akihiro Takemiya, Koji Hasegawa, Takeshi Kimura, Koh Ono
Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis. Life science alliance 6 (8) (2023)
Kosuke Chiba, Takao Yamaguchi, Satoshi Obika
Development of 8-17 XNAzymes that are functional in cells. Chemical science 14 (28) (2023)
Kenta Ishida, Yusuke Tamenori, Hidekazu Hoshino, Takumi Okuda, Satoshi Obika
Systematic Analysis of 2'- O -Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties. Molecules (Basel, Switzerland) 28 (23) (2023)
Tokuyuki Yoshida, Kunihiko Morihiro, Yuki Naito, Atsushi Mikami, Yusuke Tamenori, Takao Inoue, Satoshi Obika
Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides. Nucleic acids research 50 (13) (2022)
Takashi Osawa, Qin Ren, Satoshi Obika
Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3'-End. Molecules (Basel, Switzerland) 27 (23) (2022)
Yota Sakurai, Takao Yamaguchi, Tokuyuki Yoshida, Masahiko Horiba, Takao Inoue, Satoshi Obika
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2 ' -OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase. The Journal of organic chemistry 88 (1) (2022)
Ryosuke Kita, Takashi Osawa, Satoshi Obika
Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis. RSC chemical biology 3 (6) (2022)
Fahad Hussain, Fahad Imtiaz Rahman, Poushali Saha, Atsushi Mikami, Takashi Osawa, Satoshi Obika, S M Abdur Rahman
Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials. Molecules (Basel, Switzerland) 27 (11) (2022)
Yota Sakurai, Takao Yamaguchi, Tokuyuki Yoshida, Masahiko Horiba, Takao Inoue, Satoshi Obika
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2 ' -OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase. The Journal of organic chemistry 88 (1) (2022)
Takashi Osawa, Qin Ren, Satoshi Obika
Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3'-End. Molecules (Basel, Switzerland) 27 (23) (2022)
Takashi Sasaki, Yoko Hirakawa, Fumiko Yamairi, Takashi Kurita, Karin Murahashi, Hirokazu Nishimura, Norihiko Iwazaki, Hidenori Yasuhara, Takashi Tateoka, Tetsuya Ohta, Satoshi Obika, Jun Kotera
Altered Biodistribution and Hepatic Safety Profile of a Gapmer Antisense Oligonucleotide Bearing Guanidine-Bridged Nucleic Acids. Nucleic acid therapeutics 32 (3) (2022)
Shinji Kumagai, Hiroaki Sawamoto, Tomo Takegawa-Araki, Yuuki Arai, Shuhei Yamakoshi, Katsuya Yamada, Tetsuya Ohta, Eiji Kawanishi, Naohiro Horie, Takao Yamaguchi, Satoshi Obika
Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides. Organic & biomolecular chemistry 18 (46) (2022)
Shogo Omuro, Takao Yamaguchi, Taiji Kawase, Maki Terasaki, Kenji Hirose, Satoshi Obika
Physicochemical property evaluation of modified oligonucleotides by traveling-wave ion mobility mass spectrometry. Rapid communications in mass spectrometry : RCM 36 (10) (2022)
Tomo Takegawa-Araki, Shinji Kumagai, Kai Yasukawa, Masataka Kuroda, Takashi Sasaki, Satoshi Obika
Structure-Activity Relationships of Anti-microRNA Oligonucleotides Containing Cationic Guanidine-Modified Nucleic Acids. Journal of medicinal chemistry 65 (3) (2022)
Tomo Takegawa-Araki, Kai Yasukawa, Norihiko Iwazaki, Hideto Maruyama, Hiroyuki Furukawa, Hiroaki Sawamoto, Satoshi Obika
Parallel synthesis of oligonucleotides containing N -acyl amino-LNA and their therapeutic effects as anti-microRNAs. Organic & biomolecular chemistry 20 (47) (2022)
Yota Sakurai, Takao Yamaguchi, Tokuyuki Yoshida, Masahiko Horiba, Takao Inoue, Satoshi Obika
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2 ' -OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase. The Journal of organic chemistry (2022)
Yota Sakurai, Takao Yamaguchi, Tokuyuki Yoshida, Masahiko Horiba, Takao Inoue, Satoshi Obika
Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2 ' -OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase. The Journal of organic chemistry 88 (1) (2022)
Takashi Osawa, Qin Ren, Satoshi Obika
Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3'-End. Molecules (Basel, Switzerland) 27 (23) (2022)
Takashi Osawa, Qin Ren, Satoshi Obika
Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3'-End. Molecules (Basel, Switzerland) 27 (23) (2022)
Hiro Uemachi, Yusuke Tamenori, Keisuke Tanaka, Takumi Okuda, Yoshihiro Yoneda, Satoshi Obika
Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity. Pharmaceutics 13 (6) (2021)
Hayato Fukusumi, Kazuyuki Togo, Miho Sumida, Masayuki Nakamori, Satoshi Obika, Kousuke Baba, Tomoko Shofuda, Daisuke Ito, Hideyuki Okano, Hideki Mochizuki, Yonehiro Kanemura
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication. FEBS open bio 11 (2) (2021)
Naohiro Horie, Takao Yamaguchi, Shinji Kumagai, Satoshi Obika
Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases. Beilstein journal of organic chemistry 17 (2021)
Muthuraj Prakash, Yukihiro Itoh, Yoshie Fujiwara, Yukari Takahashi, Yuri Takada, Paolo Mellini, Elghareeb E Elboray, Mitsuhiro Terao, Yasunobu Yamashita, Chika Yamamoto, Takao Yamaguchi, Masayuki Kotoku, Yuki Kitao, Ritesh Singh, Rohini Roy, Satoshi Obika, Makoto Oba, Dan Ohtan Wang, Takayoshi Suzuki
Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach. Journal of medicinal chemistry 64 (21) (2021)
Osamu Nakagawa, Hiroshi Aoyama, Akane Fujii, Yuki Kishimoto, Satoshi Obika
Crystallographic Structure of Novel Types of AgI -Mediated Base Pairs in Non-canonical DNA Duplex Containing 2'-O,4'-C-Methylene Bridged Nucleic Acids. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (11) (2021)
Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba, Kaho Oh, Asako Yamayoshi, Satoshi Obika, Mariko Harada-Shiba
Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides. Pharmaceutics 13 (6) (2021)
Takenori Shimo, Yusuke Nakatsuji, Keisuke Tachibana, Satoshi Obika
Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids. International journal of molecular sciences 22 (7) (2021)
Chisato Terada, Fumito Wada, Mei Uchida, Yukari Yasutomi, Kaho Oh, Seiya Kawamoto, Yukina Kayaba, Asako Yamayoshi, Mariko Harada-Shiba, Satoshi Obika, Tsuyoshi Yamamoto
Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides. Nucleic acid therapeutics (2021)
Yuki Kishimoto, Akane Fujii, Osamu Nakagawa, Satoshi Obika
Enhanced duplex- and triplex-forming ability and enzymatic resistance of oligodeoxynucleotides modified by a tricyclic thymine derivative. Organic & biomolecular chemistry 19 (37) (2021)
Yuki Kishimoto, Osamu Nakagawa, Akane Fujii, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika
2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (7) (2020)
Masahiko Horiba, Takao Yamaguchi, Satoshi Obika
Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages. The Journal of organic chemistry 85 (4) (2020)
Jun Koseki, Masamitsu Konno, Ayumu Asai, Naohiro Horie, Kenta Tsunekuni, Koichi Kawamoto, Satoshi Obika, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA. Scientific reports 10 (1) (2020)
Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold. Molecules (Basel, Switzerland) 25 (7) (2020)
Hidekazu Hoshino, Yuuya Kasahara, Masayasu Kuwahara, Satoshi Obika
DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences. Journal of the American Chemical Society 142 (51) (2020)
Yoshihiro Moai, Hidekazu Hiroaki, Satoshi Obika, Tetsuya Kodama
Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base. Nucleosides, nucleotides & nucleic acids 39 (1-3) (2019)
Akane Fujii, Osamu Nakagawa, Yuki Kishimoto, Yusuke Nakatsuji, Natsumi Nozaki, Satoshi Obika
Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties. Chembiochem : a European journal of chemical biology 21 (6) (2019)
Takashi Osawa, Han Kim, Misa Shoji, Miku Saijo, Masakazu Dohi, Yuta Ito, Satoshi Obika, Yoshiyuki Hari
Synthesis of 2'-C,4'-C-Methyleneoxy-Bridged Thymidine Derivatives and Properties of Modified Oligonucleotides. The Journal of organic chemistry 84 (21) (2019)
Tsunekazu Mizushima, Shinji Matsumoto, Suguru Hirota, Hirokazu Kimura, Shinsuke Fujii, Yuuya Kasahara, Hidetoshi Gon, Toshihiko Yoshida, Tomoo Itoh, Naotsugu Haraguchi, Tsunekazu Mizushima, Takehiro Noda, Hidetoshi Eguchi, Satoshi Nojima, Eiichi Morii, Takumi Fukumoto, Satoshi Obika, Akira Kikuchi
Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth. Molecular cancer therapeutics 18 (3) (2019)
Takaki Habuchi, Takao Yamaguchi, Satoshi Obika
Thioamide-Bridged Nucleic Acid (thioAmNA) Containing Thymine or 2-Thiothymine: Duplex-Forming Ability, Base Discrimination, and Enzymatic Stability. Chembiochem : a European journal of chemical biology 20 (8) (2019)
Takaki Habuchi, Takao Yamaguchi, Hiroshi Aoyama, Masahiko Horiba, Kosuke Ramon Ito, Satoshi Obika
Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase. The Journal of organic chemistry 84 (3) (2019)
Shinji Matsumoto, Taku Yamamichi, Koei Shinzawa, Yuuya Kasahara, Satoshi Nojima, Takahiro Kodama, Satoshi Obika, Tetsuo Takehara, Eiichi Morii, Hiroomi Okuyama, Akira Kikuchi
GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling. Nature communications 10 (1) (2019)
Takuya Uehara, Chi-Jing Choong, Masayuki Nakamori, Hideki Hayakawa, Kumiko Nishiyama, Yuuya Kasahara, Kousuke Baba, Tetsuya Nagata, Takanori Yokota, Hiroshi Tsuda, Satoshi Obika, Hideki Mochizuki
Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Scientific reports 9 (1) (2019)
Katsunori Matsushita, Takumi Okuda, Shohei Mori, Masamitsu Konno, Hidetoshi Eguchi, Ayumu Asai, Jun Koseki, Yoshifumi Iwagami, Daisaku Yamada, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Yuuya Kasahara, Kunihiko Morihiro, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii, Satoshi Obika
A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma. ChemMedChem 14 (15) (2019)
Akane Fujii, Osamu Nakagawa, Yuki Kishimoto, Takumi Okuda, Yusuke Nakatsuji, Natsumi Nozaki, Yusuke Tamenori, Satoshi Obika
1,3,9-Triaza-2-oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self-Base Pairs with Three AgI Ions in a Duplex. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (31) (2019)
Yuka Kataoka, Hiroto Fujita, Arina Afanaseva, Chioko Nagao, Kenji Mizuguchi, Yuuya Kasahara, Satoshi Obika, Masayasu Kuwahara
High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives. Biochemistry 58 (6) (2019)
Masahito Shimojo, Yuuya Kasahara, Masaki Inoue, Shin-Ichi Tsunoda, Yoshie Shudo, Takayasu Kurata, Satoshi Obika
A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer. Scientific reports 9 (1) (2019)
Osamu Nakagawa, Akane Fujii, Yuki Kishimoto, Yusuke Nakatsuji, Natsumi Nozaki, Satoshi Obika
2'-O,4'-C-Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex. Chembiochem : a European journal of chemical biology 19 (22) (2018)
Hiroaki Sawamoto, Yuuki Arai, Shuhei Yamakoshi, Satoshi Obika, Eiji Kawanishi
Synthetic Method for 2'-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction. Organic letters 20 (7) (2018)
Takenori Shimo, Keisuke Tachibana, Satoshi Obika
Construction of a tri-chromatic reporter cell line for the rapid and simple screening of splice-switching oligonucleotides targeting DMD exon 51 using high content screening. PloS one 13 (5) (2018)
Shohei Mori, Kunihiko Morihiro, Takumi Okuda, Yuuya Kasahara, Satoshi Obika
Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides. Chemical science 9 (5) (2017)
Takashi Hara, Tetsuya Kodama, Yumi Takegaki, Kunihiko Morihiro, Kosuke Ramon Ito, Satoshi Obika
Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle. The Journal of organic chemistry 82 (1) (2016)
Yasunori Mitsuoka, Tsuyoshi Yamamoto, Akira Kugimiya, Reiko Waki, Fumito Wada, Saori Tahara, Motoki Sawamura, Mio Noda, Yuko Fujimura, Yuki Kato, Yoshiyuki Hari, Satoshi Obika
Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency. The Journal of organic chemistry 82 (1) (2016)