Genomic copy number alterations as biomarkers for triple negative pregnancy-associated breast cancer.

B B M SuelmannA RademakerC van DooijeweertE van der WallP J van DiestCathy B Moelans

Published in: Cellular oncology (Dordrecht) (2022)

This study provides novel insights into the biology of triple-negative PABC tumors suggesting that CNAs, particularly 8p loss and TOP2A loss, are involved in the development of breast cancer during pregnancy. FGFR1 loss and TOP2A loss seem to be promising new biomarkers that independently identify subgroups of PABC patients with poor prognosis. These genomic biomarkers may provide clues for personalized therapy.

Keyphrases

copy number
poor prognosis
mitochondrial dna
long non coding rna
genome wide
dna methylation
stem cells
gene expression
pregnant women
pregnancy outcomes
cell therapy