The Role of Arginine Metabolism in Oral Tongue Squamous Cell Carcinoma.
Leanne Lee LeungNicolas Cheuk Hang LauJiaxun LiuXinyu QuStephen Kwok Wing TsuiJinpao HouCherie Tsz-Yiu LawTung Him NgJudy Wai Ping YamChit ChowAmy B W ChanJason Ying-Kuen ChanKatie L MeehanPublished in: Cancers (2021)
Early diagnosis and treatment do not prevent the high morbidity and poor prognosis of oral tongue squamous cell carcinoma (TSCC). Earlier studies have shown that ARG1 signaling is deregulated in TSCC. Here, we investigated the complexity of ARG1 metabolism in this cancer subsite to appreciate the therapeutic potential of this potential biological vulnerability. Various functional studies show that ARG1 overexpression in oral cancer cells inhibits cell proliferation and invasion compared with controls. Further, RNA-sequencing revealed numerous differentially expressed genes (DEGs) and associated networks were dysregulated by ARG1 overexpression, including hypoxia-inducible factor (HIFα) signaling, the natural killer cell signaling pathway and interferon signaling. Our work provides a foundation for understanding the mechanism of action of disrupted arginine metabolism in oral tongue squamous cell carcinoma. This may impact the community for developing further therapeutic approaches.
Keyphrases
- squamous cell carcinoma
- poor prognosis
- single cell
- signaling pathway
- nitric oxide
- long non coding rna
- lymph node metastasis
- healthcare
- cell therapy
- locally advanced
- transcription factor
- gene expression
- climate change
- epithelial mesenchymal transition
- genome wide
- stem cells
- immune response
- mental health
- mass spectrometry
- case control
- pi k akt
- radiation therapy
- risk assessment
- high resolution
- single molecule
- nk cells