Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation.
Christopher E BrightlingKoirobi HaldarPamela Jane McDowellJohn BusbyVijay MistryClaudia MicieliVanessa BrownCiara CoxFreda YangCatherine BorgRahul ShrimankerMohammadali Yavari RamshehTim HardmanJoseph ArronPeter BraddingDouglas CowanAdel Hasan MansurStephen J FowlerJim LordanAndrew Menzies-GowDouglas RobinsonJohn MatthewsIan Douglas PavordRekha ChaudhuriLiam G HeaneyMichael R BarerChristopher Brightlingnull nullPublished in: Allergy (2022)
High FeNO could indicate a subgroup of severe asthma less likely to benefit from antimicrobial strategies at exacerbation or in the context of poor control. Where FeNO is <50 ppb, biomarkers of microbial composition are required to identify those likely to respond to microbiome-directed strategies. We found no evidence that mepolizumab alters airway microbial composition.