EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling.

Xing-Kang JiangShanqi GuoShuo WangYangyi ZhangHaojie ChenYong WangRanlu LiuYuanjie NiuYong Xu

Published in: Cancer research (2022)

Upregulation of a novel circRNA, circARHGAP29, promotes docetaxel resistance and glycolytic metabolism, suggesting it could be a prognostic biomarker and therapeutic target in chemoresistant prostate cancer.

Keyphrases

prostate cancer
radical prostatectomy
locally advanced
high glucose
poor prognosis
cell proliferation
diabetic rats
high intensity
signaling pathway
drug induced
squamous cell carcinoma
binding protein
radiation therapy
long non coding rna
rectal cancer
growth hormone