Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression.
Dana K MitchellBreanne BurgessEmily E WhiteAbbi Elise SmithElizabeth A Sierra PotchanantHenry Elmer MangBrooke E HickeyQingbo LuShaomin QianWaylan BesslerXiaohong LiLi JiangKylee BrewsterConstance J TemmAndrew E HorvaiEric A AlbrightMelissa L FishelChristine A PratilasSteven P AngusD Wade ClappSteven D RhodesPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
If validated prospectively in future studies, these signatures may serve as molecular diagnostic tools to augment conventional histopathologic diagnosis by identifying neurofibromas at high risk of undergoing malignant transformation, facilitating risk-adapted care.
Keyphrases
- peripheral nerve
- gene expression
- healthcare
- signaling pathway
- palliative care
- dna methylation
- poor prognosis
- public health
- current status
- lps induced
- quality improvement
- single cell
- transcription factor
- oxidative stress
- pi k akt
- case control
- affordable care act
- inflammatory response
- single molecule
- cell proliferation
- immune response
- chronic pain