Investigation of YAP-1, OTX-2, and nestin protein expressions in neuroblastoma: a preliminary study.

Selen Kum Özşengezer Zekiye Sultan Altun Gamze Sanlav Burçin Baran Deniz Kizmazoglu Safiye Aktaş Pembe Keskinoglu Hatice Nur Olgun

Published in: Annals of clinical and translational neurology (2024)

The findings of this study support that YAP-1 may be a potential prognostic biomarker for staging and risk-group assignment of NB patients. YAP-1 expression in neuroblastoma is associated with significantly poorer survival probabilities and should be considered as a potential therapeutic target. OTX-2 is a promising predictive biomarker candidate, but its mechanisms need further investigation in neuroblastoma, as nestin expression is not significantly linked to patient survival.

Keyphrases

poor prognosis
end stage renal disease
ejection fraction
binding protein
chronic kidney disease
newly diagnosed
lymph node
case report
prognostic factors
long non coding rna
pet ct
patient reported outcomes
risk assessment
protein protein