M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.
Eva M Garrido-MartinToby W P MellowsJames ClarkeAnusha-Preethi GanesanOliver WoodAngelica CazalyGregory SeumoisSerena J CheeAiman AlzetaniEmma V KingCatherine C HedrickGareth ThomasPeter S FriedmannChristian Hermann OttensmeierPandurangan VijayanandTilman Sanchez-ElsnerPublished in: Journal for immunotherapy of cancer (2021)
We showed that in early lung cancer, expression of M1-like and M2-like gene signatures are not mutually exclusive since the same TAMs can simultaneously display both gene-expression profiles. The presence of M1hot TAMs was associated with a strong TRM tumor-infiltrate and better outcomes. Thus, therapeutic approaches to re-program TAMs to an M1hot phenotype are likely to augment the adaptive antitumor responses.