Absolute count of leukemic blasts in cerebrospinal fluid as detected by flow cytometry is a relevant prognostic factor in children with acute lymphoblastic leukemia.
Alexander M PopovGuenter HenzeTatiana VerzhbitskayaJulia RoumiantsevaSvetlana LagoykoOlga KhlebnikovaOlga StrenevaOleg BidanovGrigory TsaurHiroto InabaAlexander KarachunskiyLarisa FechinaPublished in: Journal of cancer research and clinical oncology (2019)
Our data do not support the concept of re-stratification and modification of therapy based on qualitative CSF investigation by MFC. However, MFC is a highly sensitive technique of CSF investigation improving the definition of CNS involvement in childhood ALL, and quantitative measurement of blast cells in CSF, if well-organized, can be a useful additional tool for stratification of patients in clinical trials.
Keyphrases
- prognostic factors
- cerebrospinal fluid
- acute lymphoblastic leukemia
- flow cytometry
- clinical trial
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- randomized controlled trial
- systematic review
- peritoneal dialysis
- acute myeloid leukemia
- cell cycle arrest
- blood brain barrier
- mesenchymal stem cells
- patient reported outcomes
- cell death
- big data
- living cells
- smoking cessation
- simultaneous determination
- label free