Development of a Plasminogen Population PK model supporting prophylactic replacement therapy for Plasminogen deficient patients within the WAPPS-Hemo platform.

Pierre ChelleDagmar HajducekKaren ThibaudeauNicholas HobsonAlfonso Iorio Amy D Shapiro Andrea N Edginton

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2024)

The model was integrated into the WAPPS-Hemo webservice to help individualize prophylactic treatment in plasminogen deficient patients. Prospective PK data to be collected through the WAPPS-Hemo database will be used to better understand plasminogen PK and improve patient care.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
emergency department
patient reported outcomes
high throughput
big data
electronic health record
artificial intelligence
deep learning