Redox-Neutral Cyanoalkylation/Cyclization of Olefinic 1,3-Dicarbonyls with Cycloketone Oxime Esters: Access to Cyanoalkylated Dihydrofurans.

Jia-Yu ZhangXin-Hua DuanJun-Cheng YangLi Na Guo

Published in: The Journal of organic chemistry (2018)

Metal-catalyzed cyanoalkylation/cyclization of olefinic 1,3-dicarbonyls with cycloketone oxime esters has been developed under redox-neutral conditions. This protocol provided a straightforward approach to diverse cyanoalkylated 2,3-dihydrofurans via a tandem ring-opening/addition/cyclization process.

Keyphrases

randomized controlled trial
room temperature
electron transfer
visible light