Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor γ.

Isabel KarkossaTommy HofmannSandra RotherRita SchlichtingRocco MorettiDieter ScharnweberVera HintzeBeate I EscherJens MeilerStefan KalkhofMartin von Bergen

Published in: Rapid communications in mass spectrometry : RCM (2019)

In summary, this study gives structural insights into the direct interaction of PPARγ with MEHP and MEOHP and shows that the DEHP transformation products may modulate the lipid metabolism through PPARγ pathways.

Keyphrases

insulin resistance
fatty acid
escherichia coli
biofilm formation
metabolic syndrome
adipose tissue
cystic fibrosis