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Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.

Arin NamShashi JainChengsheng WuAlejandro D CamposRyan M ShepardZiqi YuJoshua P ReddyTami Von SchalschaSara M WeisMark OnaitisHiromi I WetterstenDavid A Cheresh
Published in: Cancer research (2024)
Upregulation of integrin αvβ3, a cancer stem cell marker, in response to nutrient stress activates sustained AMPK/PGC1α signaling that induces metabolic reprogramming in lung cancer cells to support their survival. See related article by xxxx, p. xx.
Keyphrases
  • cancer stem cells
  • skeletal muscle
  • poor prognosis
  • cell proliferation
  • signaling pathway
  • single cell
  • stress induced
  • cell therapy
  • cell adhesion
  • cell migration
  • stem cells
  • heat stress
  • long non coding rna
  • free survival