Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.
Arin NamShashi JainChengsheng WuAlejandro D CamposRyan M ShepardZiqi YuJoshua P ReddyTami Von SchalschaSara M WeisMark OnaitisHiromi I WetterstenDavid A ChereshPublished in: Cancer research (2024)
Upregulation of integrin αvβ3, a cancer stem cell marker, in response to nutrient stress activates sustained AMPK/PGC1α signaling that induces metabolic reprogramming in lung cancer cells to support their survival. See related article by xxxx, p. xx.