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The Effect of Long COVID-19 Infection and Vaccination on Male Fertility; A Narrative Review.

Soheila PourmasumiAlireza NazariZahra AhmadiSophia N KouniCesare de GregorioIoanna KoniariPeriklis DousdampanisVirginia MplaniPanagiotis PlotasStelios F AssimakopoulosChristos GogosGeorgios AidonisdisPavlos RoditisNikos MatsasDimitrios VelissarisGianfranco CalogiuriMing-Yow HungServet AltayNicholas George Kounis
Published in: Vaccines (2022)
Earlier research has suggested that the male reproductive system could be particularly vulnerable to SARS-CoV-2 (COVID-19) infection, and infections involving this novel disease not only pose serious health threats but could also cause male infertility. Data from multi-organ research during the recent outbreak indicate that male infertility might not be diagnosed as a possible consequence of COVID-19 infection. Several review papers have summarized the etiology factors on male fertility, but to date no review paper has been published defining the effect of COVID-19 infection on male fertility. Therefore, the aim of this study is to review the published scientific evidence regarding male fertility potential, the risk of infertility during the COVID-19 pandemic, and the impact of COVID-19 vaccination on the male reproductive system. The effects of COVID-19 infection and the subsequent vaccination on seminal fluid, sperm count, sperm motility, sperm morphology, sperm viability, testes and sex hormones are particularly reviewed.
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