Efficacy and safety of aflibercept plus chemotherapy in metastatic colorectal cancer: A systematic review and PRISMA-Compliant single-arm Meta-Analysis of noncomparative clinical studies and randomized controlled trials.

Ge PuAbudurosuli ReyilaXin-Yi LiSi-Yu LiuYi-Xuan JiangYa-Jie YangXia-Lei LiYing Bian

Published in: Journal of clinical pharmacy and therapeutics (2022)

Analysis of data from randomized controlled trials(RCT) and single-arm clinical trials confirmed the good efficacy of aflibercept plus chemotherapy in mCRC, while the safety of the treatment is concerning.

Keyphrases

metastatic colorectal cancer
randomized controlled trial
clinical trial
locally advanced
meta analyses
age related macular degeneration
big data
systematic review
squamous cell carcinoma
radiation therapy
chemotherapy induced
machine learning
phase ii
combination therapy
double blind