CCR10+ ILC2s with ILC1-like properties exhibit a protective function in severe allergic asthma.

Chloé BeuraudVincent LombardiSonia LuceStéphane HoriotEmmanuel NalineCatherine NeukirchSabi AiroucheThibaut PerchetRachel GolubPhilippe DevillierSylvie Chollet-MartinVéronique Baron-BodoEmmanuel NonyMichel AubierLaurent MascarellPhilippe Moingeon

Published in: Allergy (2018)

Frequencies of circulating CCR10+ ILC2s and CCL27 plasma concentrations represent candidate markers of asthma severity. The characterization of CCR10+ ILC2s in human samples and in mouse asthma models suggests that these cells downregulate allergic inflammation through IFN-γ production.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
dendritic cells
lung function
nk cells
regulatory t cells
induced apoptosis
endothelial cells
oxidative stress
cystic fibrosis
cell cycle arrest
air pollution
pluripotent stem cells
liver fibrosis