KRT17 From Keratinocytes With High Glucose Stimulation Inhibit Dermal Fibroblasts Migration Through Integrin α11.

Peng ZhouYiqing LiShan ZhangDian-Xi ChenRuikang GaoPeiliang QinChao Yang Qin Li

Published in: Journal of the Endocrine Society (2024)

Increased expression of KRT17 in diabetic pathological surroundings inhibits fibroblast migration by downregulating the expression of ITGA11. Thus, KRT17 may be a molecular target for the treatment of diabetic wounds.

Keyphrases

wound healing
high glucose
poor prognosis
type diabetes
endothelial cells
binding protein
extracellular matrix
single molecule
combination therapy
cell migration