Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimens.

Kee Kiat YeoAshley S MargolRebekah J KennedyLong HungNathan J RobisonGirish DhallShahab Asgharzadeh

Published in: Journal of neuro-oncology (2019)

The majority of young children with SHH-subgroup medulloblastoma can be treated effectively with irradiation-sparing regimens. Our results support the use of chemotherapy-only strategies for upfront treatment of young children with SHH medulloblastoma, while demonstrating the urgent need for intensification/augmentation of treatment for patients with group 3/4 medulloblastoma.

Keyphrases

squamous cell carcinoma
randomized controlled trial
robot assisted
newly diagnosed
replacement therapy
phase iii