Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC.
Marta Perez-Hernandez DuranChantal J M van OpbergenNavratan BagwanChristoffer Rasmus VissingGrecia M Marrón-LiñaresMingliang ZhangEstefania Torres VegaAndrea SorrentinoLylia DriciKarolina SulekRuxu ZhaiFinn B HansenAlex Hoerby ChristensenSøren BoesgaardFinn GustafssonKasper RossingEric M SmallMichael Jonathan DaviesEli RothenbergPriscila Y SatoMarina CerroneThomas Hartvig Lindkær JensenKlaus QvortrupHenning BundgaardMario DelmarAlicia LundbyPublished in: Circulation (2022)
). We propose therapies that limit oxidant formation as a possible intervention to restrict DNA damage in ARVC.