The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells.

Clayton WhitmoreEvan P S PrattLuke AndersonKevin BradleySawyer M LatourMariam N HashmiAlbert K UrazaevRod WeilbaecherJudith K DavieWen-Horng WangGregory H HockermanAmber L Pond

Published in: Skeletal muscle (2020)

Human ERG1A expression increases both intracellular calcium concentration and combined calpain 1 and 2 activity. The increased calpain activity is likely a result of the increased calcium levels and decreased calpastatin abundance.

Keyphrases

skeletal muscle
endothelial cells
poor prognosis
induced apoptosis
type diabetes
adipose tissue
cell cycle arrest
signaling pathway
cell proliferation
cell death
antibiotic resistance genes
microbial community
induced pluripotent stem cells