Cirsium japonicum var. Maackii Improves Cognitive Impairment under Amyloid Beta 25-35 -Induced Alzheimer's Disease Model.

Abnormal production and degradation of amyloid beta (A β ) in the brain lead to oxidative stress and cognitive impairment in Alzheimer's disease (AD). Cirsium japonicum var. maackii (CJM) is widely used as an herbal medicine and has antibacterial and anti-inflammatory properties. This study focused on the protective effect of the ethyl acetate fraction from CJM (ECJM) on A β 25-35 -induced control mice. In the T-maze and novel object recognition test, ECJM provided higher spatial memory and object recognition compared to A β 25-35 treatment alone. In the Morris water maze test, ECJM-administered mice showed greater learning and memory abilities than A β 25-35 -induced control mice. Additionally, ECJM-administered mice experienced inhibited lipid peroxidation and nitric oxide production in a dose-dependent manner. The present study indicates that ECJM improves cognitive impairment by inhibiting oxidative stress in A β 25-35 -induced mice. Therefore, CJM may be useful for the treatment of AD and may be a potential material for functional foods.