Inflammation and bone mineral density: A Mendelian randomization study.
Jian V HuangCatherine Mary SchoolingPublished in: Scientific reports (2017)
Osteoporosis is a common age-related disorder leading to an increase in osteoporotic fractures and resulting in significant suffering and disability. Inflammation may contribute to osteoporosis, as it does to many other chronic diseases. We examined whether inflammation is etiologically relevant to osteoporosis, assessed from bone mineral density (BMD), as a new potential target of intervention, or whether it is a symptom/biomarker of osteoporosis. We obtained genetic predictors of inflammatory markers from genome-wide association studies and applied them to a large genome wide association study of BMD. Using two-sample Mendelian randomization, we obtained unconfounded estimates of the effect of high-sensitivity C-reactive protein (hsCRP) on BMD at the forearm, femoral neck, and lumbar spine. After removing potentially pleiotropic single nucleotide polymorphisms (SNPs) possibly acting via obesity-related traits, hsCRP, based on 16 SNPs from genes including CRP, was not associated with BMD. A causal relation of hsCRP with lower BMD was not evident in this study.
Keyphrases
- bone mineral density
- postmenopausal women
- body composition
- genome wide
- oxidative stress
- genome wide association
- genome wide association study
- randomized controlled trial
- insulin resistance
- weight loss
- multiple sclerosis
- dna methylation
- risk assessment
- gene expression
- body mass index
- skeletal muscle
- high fat diet induced
- copy number
- human health
- patient reported