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Hierarchical Bayesian modeling of heterogeneous outcome variance in cluster randomized trials.

Guangyu TongJiaqi TongYi JiangDenise A EssermanMichael O HarhayJoshua L Warren
Published in: Clinical trials (London, England) (2024)
We proposed new hierarchical Bayesian variance models to accommodate cluster-specific variances in cluster randomized trials. The newly developed methods inform the understanding of how an intervention strategy is implemented and disseminated differently across clusters and can help improve future trial design.
Keyphrases
  • randomized controlled trial
  • clinical trial
  • phase iii
  • current status
  • open label