A 24-month metformin treatment study of children with obesity: Changes in circulating GDF-15 and associations with changes in body weight and visceral fat.

Gemma Carreras BadosaAriadna Gómez-VilarrublaBerta Mas-ParésJosé-María Martínez-CalcerradaSilvia Xargay-TorrentAnna Prats-PuigElsa Puerto-CarranzaFerran Díaz-RoldánFrancis de ZegherLourdes IbañezJudit Bassols Abel López-Bermejo

Published in: Pediatric obesity (2021)

In conclusion, the concept that GDF-15 is among the mediators of metformin's normalizing effects in individuals with obesity is herewith extended into childhood.

Keyphrases

body weight
insulin resistance
metabolic syndrome
weight loss
adipose tissue
type diabetes
high fat diet induced
weight gain
young adults
fatty acid
early life