Anti-inflammatory and anti-Candida Effects of Brazilian Organic Propolis, a Promising Source of Bioactive Molecules and Functional Food.
Bruno Dias NaniJanaína de Cássia Orlandi SardiJosy Goldoni LazariniDiego Romário SilvaAdna Prado MassariolliThiago Mattar CunhaSeverino Mathias de AlencarMarcelo FranchinPedro Luiz RosalenPublished in: Journal of agricultural and food chemistry (2019)
Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing nuclear factor κB activation, tumor necrosis factor α release, and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsisolis and reduced in vitro yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in Galleria melonella larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-dicaffeoylquinic acid, quercetin, and gibberellins A7, A9, and A20, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food.
Keyphrases
- candida albicans
- biofilm formation
- anti inflammatory
- nuclear factor
- cell adhesion
- toll like receptor
- oxidative stress
- pseudomonas aeruginosa
- electronic health record
- human health
- single cell
- staphylococcus aureus
- induced pluripotent stem cells
- artificial intelligence
- data analysis
- wound healing
- drosophila melanogaster