Beyond Alternans: Detection of Higher-Order Periodicity in Ex-Vivo Human Ventricles Before Induction of Ventricular Fibrillation.
Shahriar IravanianIlija UzelacAnand D ShahMikael J ToyeMichael S LloydMichael A BurkeMani A DaneshmandTamer S AttiaJ David VegaFaisal M MerchantElizabeth M CherryNeal K BhatiaFlavio H FentonPublished in: bioRxiv : the preprint server for biology (2023)
We present evidence of higher-order periodicities and the co-existence of such regions with stable non-chaotic areas in ex-vivo human hearts before VF induction. This result is consistent with the period-doubling route to chaos as a possible mechanism of VF initiation, which complements the concordant to discordant alternans mechanism. The presence of higher-order regions may act as niduses of instability that can degenerate into chaotic fibrillation.