A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors.

Kristýna NěmejcovaMichaela Kendall BártůRomana MichálkováJana DrozenováPavel FabianOluwole FadareJitka HausnerováJan LacoRadoslav MatějGábor MéhesNaveena SinghSimona StolnicuPetr ŠkapaMarián ŠvajdlerIvana StružinskáDavid CibulaRoman KocianSigurd F LaxW Glenn McCluggagePavel Dundr

Published in: Diagnostic pathology (2023)

Concerning differential diagnosis our results imply that despite the differences in expression in the different ovarian tumor types, the practical value for diagnostic purposes is limited. Contrary to other solid tumors, we did not find prognostic significance of IMP3 in ovarian cancer, with the exception of RFS in low grade serous carcinomas. However, the high expression of IMP2 and IMP3 could be of predictive value in ovarian carcinomas since IMP proteins are potential therapeutical targets.

Keyphrases

high grade
low grade
poor prognosis
binding protein
long non coding rna