Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP NL-F/NL-F Mice.

Yimin Fang Mackenzie R PeckKathleen QuinnDavid MedinaStephen RoySamuel A McFadden Andrzej BartkeKevin N HascupErin R Hascup

Published in: bioRxiv : the preprint server for biology (2023)

mice; (b) sex-dependent factors that contribute to adiposity changes after senolytic administration; and (c) changes in estrogen across the AD continuum and its potential role in modulating senolytic treatment.

Keyphrases

high fat diet induced
insulin resistance
randomized controlled trial
weight gain
signaling pathway
wild type
type diabetes
adipose tissue
skeletal muscle